Antihyperlipidemic Drugs

Question Answer
LDL goal w/o CHD < 2 RF < 160 mg/dl
LDL goal w/o CHD 2+ RF < 130 mg/dl
LDL goal w/ CHD or risk equivalents (DM or multiple risk factors) < 70-100 mg/dl
Bind bile acids in intestine, prevent fat abs Bile Acid Sequestrants MOA
Belching, bloating, constipation, unpleasant taste Bile Acid Sequestrants ADRs
Cholestyramine, Colestipol, Colesevelam Bile Acid Sequestrants
Reduction in hepatic production of VLDL (Lowers LDL) Niacin
Flushing, pruritus, rash, uticaria Niacin
#1 Hepatotoxicity, gastritis/GI bleeding, hyperglycemia, gout, myalgias Niacin ADRs
Diabetes, active gout, PUD, severe gastritis Niacin contraindications
Inhibition of intracellular synthesis of cholesterol HMG CoA Reductase Inhibitors (Statins) MOA
Hepatotoxicity, myopathy HMG CoA Reductase Inhibitors (Statins) MOA
Lower LDL Statins
Best drug to raise HDL Niacin
Catabolism of VLDL FIbric Acid Derivitaves
Dyspepsia, abdominal pain Common ADRs of Fibric Acid Derivatives
Gemfibrozil FIbric Acid Derivative
Fenofibrate FIbric Acid Derivative
Ezetimibe FIbric Acid Derivative
Cholilithiasis, myopathy, hepatitis Potentially serious ADRs of Fibric Acid Derivatives
Inhibits transport of cholesterol across intestinal wall Ezetimibe MOA
Monotherapy or combo therapy w/ statins for treatment of primary hypercholesterolemia (approx 15% reduction in LDL) Ezetimibe
Active liver disease, persistently elevated serum transaminases Ezetimibe Contraindications

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