Chromosomal Instability and Aging-Basic Science and clinical Applicati

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Chromosomal Instability and Aging-Basic Science and clinical Applications















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Examines the relationship between DNA damage and repair, cellular senescence, genomic instability, and aging. Includes in-depth discussions of various types of damage, DNA repair network, and cellular responses to genetic damage.

Twenty-four contributions from international scientists discuss recent research on the relationships between genomic instability and aging. A number of chapters deal with the role of chromosomal telomere shortening as a contributor to aging, while others look at the premature aging associated with such genetically linked conditions as Fanconi anemia and Down syndrome. The volume concludes with several contributions on aging in model organisms such as yeast and mice.







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